The LiquiScan-ES system is designed for rapid, high resolution analysis of colloid sizes of nanoparticles, proteins and other macromolecules down to 2.5 nm, covering a mass range from 8 kDa to> 100 MDa. The strength of the LiquiScan-ES system is its ability to analyze nanoparticles and macromolecules that are too large for mass spectrometry, but with a level of accuracy and resolution that is unattainable for light scattering detectors. While other products used for particle sizing in liquids try to cover a wide range of sizes, LiquiScan-ES focuses on the best performance for the nanometer range of particle sizes, resulting in quality data for research.